Report error Found 62 Enz. Inhib. hit(s) with all data for entry = 50002723
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 0.370nMAssay Description:Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 0.380nMAssay Description:Inhibition of recombinant HIV protease expressed in inclusion bodies of Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587,G537V,H558K,V571A](Human immunodeficiency virus)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Inhibition of HIV proteaseMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 3.80nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 34nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 107nMAssay Description:Inhibition of bovine alpha-chymotrypsin using succinyl Ala-Ala-Pro-Phe-p-nitroanilide as substrate after 1 hr by Dixon plot analysisMore data for this Ligand-Target Pair
Affinity DataKi: 206nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 243nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 460nMAssay Description:Displacement of [3H]-DTG from sigma-2 receptor in rat liver membranes after 180 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His-tagged XIAP BIR3 domain (241 to 356 residues) (unknown origin) using fluorescein labeled SMAC peptide as substrate after...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of rabbit lung ACE using N-[3-(2-furyl)acryloyl]-Phe-Gly-Gly as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged XIAP BIR2-3 domain (125 to 356 residues) C202A/C213G mutant (unknown origin) using fluorescein labeled SMAC pepti...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 251nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 275nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 707nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 754nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 791nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 904nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 2.63E+3nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 3.17E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 4.43E+3nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 4.72E+3nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 5.27E+3nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human recombinant HDAC2 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
Csir-National Chemical Laboratory
Curated by ChEMBL
Csir-National Chemical Laboratory
Curated by ChEMBL
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of human DAT expressed in CHOK1 cells assessed as decrease in [3H]-dopamine reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured ...More data for this Ligand-Target Pair