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Found 34 Enz. Inhib. hit(s) with all data for entry = 50018860
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataIC50:  36nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
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TargetActivin receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  68nMAssay Description:Inhibition of ALK2 (unknown origin)More data for this Ligand-Target Pair
TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  74nMAssay Description:Inhibition of BMPR2 (unknown origin)More data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))TBA
LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  95nMAssay Description:Inhibition of ALK3 (unknown origin)More data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))TBA
LigandPNGBDBM50262685(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-...)
Affinity DataIC50:  235nMAssay Description:Inhibition of ALK6 (unknown origin)More data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613308(CHEMBL5271220)
Affinity DataIC50:  461nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50:  506nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50:  630nMAssay Description:Inhibition of BMPR2 (174 to end residues) (unknown origin) using MBP as substrate incubated for 60 mins in presence of ATP by ADP Glo assayMore data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: >3.50E+3nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length lysed GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trace...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: >4.50E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length intact GSK3B (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613309(CHEMBL5278418)
Affinity DataIC50: >4.50E+4nMAssay Description:Inhibition of N-terminal NanoLuc-fused full length GSK3A (unknown origin) transfected in HEK293T cells incubated for 2 hrs in presence of tracer K8 b...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase 24(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  120nMAssay Description:Binding affinity to recombinant MST3 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant STK4 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant CDK2 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 15(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to recombinant MAPK15 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetMAP/microtubule affinity-regulating kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to recombinant MARK4 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetMAP/microtubule affinity-regulating kinase 3(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to recombinant MARK3 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant FLT1 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50308060(16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,1...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to recombinant BMPR2 (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetBMP-2-inducible protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  1nMAssay Description:Binding affinity to recombinant BMP2K (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  4.30nMAssay Description:Binding affinity to recombinant GSK3B (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613307(CHEMBL5271697)
Affinity DataKd:  84nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataKd:  186nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA
LigandPNGBDBM50613306(CHEMBL1235645)
Affinity DataKd:  324nMAssay Description:Inhibition of ALK5 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKd:  570nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetTyrosine-protein kinase Mer(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataKd:  6.40nMAssay Description:Binding affinity to recombinant MERTK (unknown origin) assessed as dissociation constant by DSF assayMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50602057(CHEMBL1908842 | JNJ-28312141)
Affinity DataKd:  310nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetBone morphogenetic protein receptor type-2(Homo sapiens (Human))TBA
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKd:  56nMAssay Description:Inhibition of BMPR2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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