Compile Data Set for Download or QSAR
maximum 50k data
Found 78 Enz. Inhib. hit(s) with all data for entry = 50018869
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50381716(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Affinity DataIC50:  13nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 10(Homo sapiens (Human))TBA
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50:  13nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50396528(CHEMBL2171128)
Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50396531(CHEMBL2171132)
Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50396549(CHEMBL2171134)
Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50396550(CHEMBL2171131)
Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50396530(CHEMBL2171133)
Affinity DataIC50: <15nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50396538(CHEMBL2171145)
Affinity DataIC50:  17nMAssay Description:Inhibition of PERK (unknown origin)More data for this Ligand-Target Pair
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TargetMitogen-activated protein kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50:  25nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50613378(CHEMBL1997822)
Affinity DataIC50:  40nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetMitogen-activated protein kinase 8(Homo sapiens (Human))TBA
LigandPNGBDBM86632(JNK-IN-7)
Affinity DataIC50:  41nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM121388(US8722890, 3)
Affinity DataIC50:  50nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50265242(3-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)-1,2...)
Affinity DataIC50:  50nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50613381(CHEMBL5278787)
Affinity DataIC50:  80nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Nek9(Homo sapiens (Human))TBA
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataIC50:  100nMAssay Description:Inhibition of NEK9 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)
Affinity DataIC50:  150nMAssay Description:Inhibition of MAP3K8 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50381716(ABT-348 | ILORASERTIB | US8722890, 1 | US8722890, ...)
Affinity DataIC50:  200nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataIC50:  274nMAssay Description:Inhibition of human NEK2More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50613382(CHEMBL5283398)
Affinity DataIC50:  280nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50315888(CHEMBL1090360 | N-(3-(5-(2-(3-morpholinophenylamin...)
Affinity DataIC50:  310nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50613379(CHEMBL1994830)
Affinity DataIC50:  316nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50265275(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)
Affinity DataIC50:  410nMAssay Description:Inhibition of MAP3K8 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50613380(CHEMBL1988153)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50613378(CHEMBL1997822)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50613382(CHEMBL5283398)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50265242(3-(4-(4-iodophenoxy)thieno[2,3-c]pyridin-2-yl)-1,2...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of MAP3K8 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM121388(US8722890, 3)
Affinity DataIC50: >3.90E+3nMAssay Description:Inhibition of NEK4 (unknown origin)More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  170nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  3.10E+3nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  5.20E+3nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataKd:  3.40E+3nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataKd:  8.30E+3nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))TBA
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataKd: <100nMAssay Description:Inhibition of NEK1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  260nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  5.30E+3nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataKd:  1.70E+3nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM6568(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Affinity DataKd:  110nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50355500(CHEMBL1908394 | US9695172, GSK461364)
Affinity DataKd:  260nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50161957(4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(p...)
Affinity DataKd:  270nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM8270(2-chloro-5-{[4-(3-methoxyphenyl)-2,5-dioxo-2,5-dih...)
Affinity DataKd:  460nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))TBA
LigandPNGBDBM50396483(PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemu...)
Affinity DataKd:  5.00E+3nMAssay Description:Inhibition of NEK2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek3(Homo sapiens (Human))TBA
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  170nMAssay Description:Inhibition of NEK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek3(Homo sapiens (Human))TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  1.00E+3nMAssay Description:Inhibition of NEK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek3(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataKd:  640nMAssay Description:Inhibition of NEK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek3(Homo sapiens (Human))TBA
LigandPNGBDBM50311017(CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...)
Affinity DataKd: <100nMAssay Description:Inhibition of NEK3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  1.80E+3nMAssay Description:Inhibition of NEK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50355496(CHEMBL1908397)
Affinity DataKd:  1.10E+3nMAssay Description:Inhibition of NEK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)
Affinity DataKd:  460nMAssay Description:Inhibition of NEK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Nek4(Homo sapiens (Human))TBA
LigandPNGBDBM50332294(CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...)
Affinity DataKd:  1.60E+3nMAssay Description:Inhibition of NEK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Nek5(Homo sapiens (Human))TBA
LigandPNGBDBM60665(BDBM50249542 | US9145414, R406 | US9212178, R406)
Affinity DataKd:  13nMAssay Description:Inhibition of NEK5 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
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