Found 16 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 4' and Ligand = 'BDBM50005711' TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataKi: 1.40E+3nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataKi: 1.45E+4nMAssay Description:Inhibition of human recombinant HDAC4 by Michaelis-Menten equation analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of human HDAC4 using fluorogenic tetrapeptide RHKKAc as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of HDAC4 in human HeLa cells incubated for 1 hr by mass spectrometry methodMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human HDAC4 using fluorescent substrate Ac-KGLGK(Ac)-MCA after 30 mins by fluorescence plate readerMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human HDAC4 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 34.8nMAssay Description:HDAC enzyme inhibition assays were performed using purified HDACs 1-10 essentially as described in Beckers et al., 2007, Int. J. Cancer., 121:1138-48...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant HDAC4 using p53 residues 379-382 (RHKKAc) as substrateMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs ...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMpH: 7.5Assay Description:Biochemical assays of HDAC activity were carried out by Nanosyn in a reaction volume of 10 ul in 384-well microplates. A standard enzymatic reaction ...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.23E+3nMpH: 8.0Assay Description:Briefly, recombinant HDACs and substrates were diluted in reaction buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7mM KCl, 1mM MgCl2, 1 mg/ml BSA, 1%...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-fused/C-terminal His-tagged HDAC4 (627 to 1084 residues) expressed in baculovirus infected Sf9 insect ...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant full-length human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate measured after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Indian Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc-Lys(trifluoroacetyl)-AMC fluorogenic acetylated peptide substrate by fluorometric assayMore data for this Ligand-Target Pair
