Found 32 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50059841' TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.0920nMAssay Description:Binding affinity of the compound against Opioid receptor mu 1 using [3H]-DAMGO in rat brain synaptosomes was determinedMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Binding affinity for rat brain P2 synaptosome Opioid receptor mu 1More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Opioid receptor mu 1 binding affinity by displacement of radioligand [3H][DAla,MePhe,Gly-ol]enkephalin (DAGO) from rat brain membrane synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Binding affinity to MOP (unknown origin)More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 0.700nMAssay Description:Binding affinity against Opioid receptor mu 1 in P2 membrane preparation of rat brain by [3H]DAGO displacement.More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-DAGO from Opioid receptor mu 1 of adult male mouse brain.More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.22nMAssay Description:Inhibition of [3H]DAGO binding to Opioid receptor mu 1 of rat brain P2 synaptosomesMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 1.22nMAssay Description:Displacement of [3H]DAMGO from rat mu opioid receptor in brain P2 synaptosomesMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in HEK293 cells preincubated for 1 hr followed by radioligand addition measured after 1 hr by liqu...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor muMore data for this Ligand-Target Pair
Affinity DataKi: 19nMAssay Description:Displacement of 2-((1E,3E,5E)-5-(1-Ethyl-3,3-dimethyl-5-sulfoindolin-2-ylidene)-penta-1,3-dien-1-yl)-1-(6-((6-((6S,7R,7aR,12bS)-9-hydroxy-7-methoxy-3...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 0.538nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.720nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Antagonist activity at mouse brain homogenate MOPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at guinea pig ileum MOPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Agonist activity at mu-opioid receptor in guinea pig ileum assessed as inhibition of electrically induced contractionsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.21nMAssay Description:In vitro inhibitory activity against electrically evoked contractions of guinea pig ileum (GPI)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of opioid receptor mu in guinea pig ileum (GPI)More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Agonist activity for Opioid receptor mu 1More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Functional bioactivity against mu opioid receptor in guinea-pig ileumMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Evaluated for its affinity towards Opioid receptor mu 1 in rat forebrain by displacing the radioligand [3H]-sufentanil.More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Agonist activity at Mu-type opioid receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Binding affinity to Mu-type opioid receptor (unknown origin)More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Displacement of [3H]- DAGO from opioid receptor mu in rat brain membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:In vitro biological activity by electrically induced smooth muscle contractions in guinea pig ileum (Opioid receptor mu 1); inhibitory concentration ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Evaluated for the inhibition of [3H]DAGO binding to mu-receptor of guinea pig brainMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University
Curated by ChEMBL
Tohoku Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:The compound was tested for binding affinity towards [3H]DAMGO, in rat Opioid receptor mu 1More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse vas deferns MOPMore data for this Ligand-Target Pair
Affinity DataEC50: 129nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein act...More data for this Ligand-Target Pair
Affinity DataEC50: 81nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-...More data for this Ligand-Target Pair
Affinity DataEC50: 10nMAssay Description:Antagonist activity at human recombinant mu opioid receptor expressed in CHO cells coexpressing alphaqi5 assessed as inhibition of dermorphin-induced...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60nMAssay Description:Negative logarithm of the molar concentration for agonist activity at mu receptor was determined in guinea pig ileumMore data for this Ligand-Target Pair
