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TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170589((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548705(CHEMBL4740159)
Affinity DataIC50: 0.960nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50140089(GCCSHPACAGNNQHIC* | CHEMBL437423)
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50049757((2R,4S)-2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2....)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of alpha-4-beta-2 nAChRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170592(CHEMBL411146)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50329473((S)-N-(1-(3-(4-(3-aminopropylamino)butylamino)prop...)
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548704(CHEMBL4791046)
Affinity DataIC50: 3.90nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50433566(CHEMBL2381566)
Affinity DataIC50: 4.20nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR overexpressed in human SHEP cells after 75 mins by liquid scintillation spectrometric analy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50548703(CHEMBL4793576)
Affinity DataIC50: 4.80nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataIC50: 4.90nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by radioligand competition analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170584(CHEMBL411145)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 3-5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50515189(CHEMBL4463134)
Affinity DataIC50: 5.40nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50437504(CHEMBL2409631)
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as inhibition of carbamylcholine-induced 86Rb+ ion efflux prei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382472(CHEMBL2024094)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity at human alpha4beta2 nACHR expressed in human SHEP1 cells assessed as inhibition of carbamylcholine-induced 86Rb+ ion efflux prei...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382472(CHEMBL2024094)
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataIC50: 7.5nMAssay Description:IC50(10′): The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302927(2-(N-tert-Butylamino)-3'-chloropentanophenone | 2-...)
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50140087(GCCSNPVCHLEHSNLC* | CHEMBL265198)
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2; Range is 0.5-8 nMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302929(2-(N-tert-Butylamino)-3'-chlorobutyrophenone | 2-(...)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50398321(CHEMBL2177344)
Affinity DataIC50: 8.60nMAssay Description:Antagonist activity at high sensitivity and low sensitivity alpha4beta2-nAChR expressed in human SH-EP1 cells assessed as inhibition of carbamylcholi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302917(2-(N-tert-Butylamino)-3'-chloro-4'-methylpropiophe...)
Affinity DataIC50: 9.20nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382466(CHEMBL2024087)
Affinity DataIC50: 9.40nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170600((3S)-3-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(...)
Affinity DataIC50: 9.60nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302924(2-(tert-Butylamino)-3',4'-dichloropentanophenone |...)
Affinity DataIC50: 9.80nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302914(2-(tert-Butylamino)-3',4'-dichlorobutyrophenone | ...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50398320(CHEMBL2177345)
Affinity DataIC50: 10.2nMAssay Description:Antagonist activity at high sensitivity and low sensitivity alpha4beta2-nAChR expressed in human SH-EP1 cells assessed as inhibition of carbamylcholi...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50428079(CHEMBL2323569 | US9303017, 25, YL-1-199)
Affinity DataIC50: 11nMAssay Description:IC50(10′): The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataIC50: 11nMAssay Description:Desensitization of human alpha4beta2 nACHR expressed in HEK293 cells assessed as inhibition of 86Rb+ efflux preincubated for 10 mins measured after 2...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)
Affinity DataIC50: 12nMAssay Description:IC50(10′): The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50048392(BUPROPION HYDROCHLORIDE | CHEMBL894 | 2-(tert-buty...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50515186(CHEMBL4462550)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302930(1-(3-bromophenyl)-2-(tert-butylamino)propan-1-one ...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50329477((S)-N-(3-(4-(3-aminopropylamino)butylamino)propyl)...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at alpha4beta2 nAChR (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced channel activatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50442930(CHEMBL3086991)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50419266(CHEMBL1835610)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine-induced 86Rb+ ion efflux by liquid...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50210334(CHEMBL3948977)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 expressed in human SH-EP1 cells assessed as reduction in carbamylcholine induced 86Rb+ efflux preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50210335(CHEMBL3898434)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 expressed in human SH-EP1 cells assessed as reduction in carbamylcholine induced 86Rb+ efflux preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50210334(CHEMBL3948977)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 expressed in human SH-EP1 cells assessed as reduction in carbamylcholine induced 86Rb+ efflux preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50210335(CHEMBL3898434)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human alpha4beta2 expressed in human SH-EP1 cells assessed as reduction in carbamylcholine induced 86Rb+ efflux preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302941(2-(N-tert-Butylamino)-4'-methylpropiophenone | 2-(...)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50428085(CHEMBL2323566 | US9303017, (S)-15, YL-1-127)
Affinity DataIC50: 18nMAssay Description:IC50(10′): The functional properties of the ligands were determined by 86Rb+ efflux assays in cells expressing α3β4 and α4β...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382467(CHEMBL2024089)
Affinity DataIC50: 18.2nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302942(2-(N-tert-Butylamino)-3'-methylpropiophenone | 2-(...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50302938(2-(tert-butylamino)-1-(3,5-dichlorophenyl)propan-1...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human alpha4beta2 nAChR receptor expressed in human SH-SY5Y cells assessed as inhibition of carbamylcholine-induced 86Rb+ effl...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Human)
The Danish University of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50382468(CHEMBL2024090)
Affinity DataIC50: 19.1nMAssay Description:Antagonist activity at human alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincuba...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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