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Found 18 of ic50 for UniProtKB: P11802
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515983(US11053238, Com. EX. 6)
Affinity DataIC50:  14nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515951(US11053238, Com. EX. 5)
Affinity DataIC50:  17nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  22nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516039(US11053238, Compound 2a | US11053238, Compound 2b)
Affinity DataIC50:  22nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataIC50:  22nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515904(4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5...)
Affinity DataIC50:  23nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516275(US11053238, Compound 15b)
Affinity DataIC50:  23nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  23nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515904(4-(6-fluoro-1- methyl-1,2,3,4- tetrahydrobenzo[4,5...)
Affinity DataIC50:  23nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515905(N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl...)
Affinity DataIC50:  31nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515923(US11053238, Compound 16b | US11053238, Example 16b)
Affinity DataIC50:  40nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515923(US11053238, Compound 16b | US11053238, Example 16b)
Affinity DataIC50:  45nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516039(US11053238, Compound 2a | US11053238, Compound 2b)
Affinity DataIC50:  108nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM515986(US11053238, Com. EX. No. 7)
Affinity DataIC50:  110nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516028(US11053238, Compound 1a | US11053238, Compound 1b)
Affinity DataIC50:  121nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516050(US11053238, Compound 15a)
Affinity DataIC50:  230nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM516065(US11053238, Compound 16a)
Affinity DataIC50: >300nMAssay Description:To demonstrate that the compounds exhibit affinity for CDK kinases (CDK2/CycA2, CDK4/CycD3, CDK6/cycD3), CDK kinase assays were performed.Reaction bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/6(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK4/6 in human MCF7 cells assessed as reduction in Rb phosphorylation at S807/811 residue incubated for 6 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed