Compile Data Set for Download or QSAR
Found 60 of ic50 for UniProtKB: P31749
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM431867(US10550114, Compound 1a)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182517(US9145392, 218)
Affinity DataIC50:  1nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50550738(CHEMBL4792262)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572156(CHEMBL4853207)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50550740(CHEMBL4780030)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182373(US9145392, 74)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182529(US9145392, 230)
Affinity DataIC50:  4nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182519(US9145392, 220)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182390(US9145392, 91)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50593633(ARQ 092 | ARQ 092 FREE BASE | ARQ-092 | Arq-092 | ...)
Affinity DataIC50:  5nMAssay Description:Inhibition of AKT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182413(US9145392, 114)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182307(US9145392, 8)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572155(CHEMBL4876889)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50550739(CHEMBL4788683)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182372(US9145392, 73)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182381(US9145392, 82)
Affinity DataIC50:  12nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182377(US9145392, 78)
Affinity DataIC50:  16nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50:  21nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182518(US9145392, 219)
Affinity DataIC50:  23nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50528416(CHEMBL4440965)
Affinity DataIC50:  44nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182337(US9145392, 38)
Affinity DataIC50:  84nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182356(US9145392, 57)
Affinity DataIC50:  140nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182367(US9145392, 68)
Affinity DataIC50:  230nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182306(US9145392, 7)
Affinity DataIC50:  260nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182361(US9145392, 62)
Affinity DataIC50:  350nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224325(US10080750, Compound 2 | US9321760, 2 | US9662330,...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182308(US9145392, 9)
Affinity DataIC50:  518nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182354(US9145392, 55)
Affinity DataIC50:  850nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182347(US9145392, 48)
Affinity DataIC50:  880nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182338(US9145392, 39)
Affinity DataIC50:  930nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182311(US9145392, 12)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224350(US10080750, Compound 27 | US9321760, 27 | US966233...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224477(US10080750, Compound 155 | US9321760, 155 | US9662...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224481(US10080750, Compound 159 | US9321760, 159 | US9662...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224329(US10080750, Compound 6 | US9321760, 6 | US9662330,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50095232(6-Methoxy-7-(3-morpholin-4-yl-propoxy)-4-(4-phenox...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of MEK1 phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM224338(US10080750, Compound 15 | US9321760, 15 | US966233...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182321(US9145392, 22)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182322(US9145392, 23)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451248(CHEMBL2368948)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451248(CHEMBL2368948)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine PKB) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50204693(3-(4'-hydroxy-biphenyl-4-yl)-1,4-dihydro-indeno[1,...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of AKT by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182336(US9145392, 37)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM182309(US9145392, 10)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50204694(3-(4'-HYDROXYBIPHENYL-4-YL)-N-(4-HYDROXYCYCLOHEXYL...)
Affinity DataIC50:  4.43E+3nMAssay Description:Inhibition of AKT by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50472751(CHEMBL2367874)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine PKB) kinaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50189603(CHEMBL377734 | N-cyclopropyl-2,4-difluoro-5-((2-(p...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of AKTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM50091042(CHEMBL2368953 | Carbonic acid (R)-2-methoxy-3-octa...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of Akt (proto-oncogenic serine/threonine) kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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