Found 56 of ic50 for monomerid = 18355 TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human lysosomal alpha glucosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of lysosomal alpha-glucosidase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of conduritol beta-epoxide-sensitive mouse glucosylceramidaseMore data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of GBA2 (unknown origin)More data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of GBA2 by HPLCMore data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of human GBA2More data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of glucosylceramidase 2 from spleen of patient with gaucher's disease by fluorimetric analysisMore data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant GBA2 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of non-lysosomal glucosylceramidase in cultured melanoma cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibitory activity against alpha-Glucosidase from riceMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of sucrase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of sucrase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of wild type C57BL/6 mouse small intestinal sucrase/isomaltase using sucrose as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method maltaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat intestinal maltase using disaccharideMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of rat intestinal maltase using moltose as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of rat intestinal isomaltase using disaccharideMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of rat intestinal isomaltase using isomoltose as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of rat liver lysosomal alpha-glucosidase using p-nitrophenyl alpha-D-glucopyranoside as substrate by colorimetric methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of maltase by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of maltase in mouse intestinal input by glucose release assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of glycogen glycogen de-branching enzyme by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Glycosidases (trehalase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of GCS assessed as amount of UDP-glucose consumed during enzyme-catalyzed reactionMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of GCS assessed as amount of UDP glucose after 3 hrs by Fluorometry analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition mouse glucosylceramide synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of glucosylceramide synthase (unknown origin) assessed as catabolism of NBD-glucosylceramideMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of porcine kidney trehalaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of rat intestinal trehalaseMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of soluble Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of golgi Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of glucosylceramide synthase in mouse RAW cells preincubated with compound for 15 mins by in-situ enzyme inhibition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of GCS by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: <5.00E+4nMAssay Description:Inhibition of lysosomal Alpha-mannosidase II in rat liverMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of glucosylceramide synthase in mouse RAW cells preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of rat intestinal sucrase using sucrose as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of rat intestinal sucrase using disaccharideMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of lactase by HPLCMore data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.58E+5nMAssay Description:Inhibition of recombinant human GAA by UV-visible spectrophotometric methodMore data for this Ligand-Target Pair
TargetLysosomal acid/Non-lysosomal glucosylceramidase(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataIC50: 1.80E+5nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 2.59E+5nMAssay Description:Inhibition of human placental beta-glucocerebrosidaseMore data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataKi: 1.16E+5nM ΔG°: -23.4kJ/mole IC50: 2.70E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii
Curated by ChEMBL
University Of Napoli Federico Ii
Curated by ChEMBL
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate prei...More data for this Ligand-Target Pair
Affinity DataIC50: 2.74E+5nMAssay Description:Inhibition of rat intestinal lactase using lactose as substrateMore data for this Ligand-Target Pair
