Found 8 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM18355' 
Affinity DataKi: 1.16E+5nM ΔG°: -23.4kJ/mole IC50: 2.70E+5nMpH: 5.5 T: 2°CAssay Description:Enzyme activity was determined as the production of fluorescent 4-MU from the substrate. The fluorescence was measured (excitation 362 nm, emission 4...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
Affinity DataIC50: 2.59E+5nMAssay Description:Inhibition of human placental beta-glucocerebrosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+5nMAssay Description:Inhibition of human GCase assessed as reduction of 4-methylumbelliferone liberation using 4-methylumbelliferyl-beta-glucopyranoside as substrate prei...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of recombinant human GBA1More data for this Ligand-Target Pair
Affinity DataIC50: 3.99E+5nMAssay Description:Inhibition of human beta-glucocerebrosidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of GBA1 (unknown origin) using beta-D-[1-14C]glucocerebroside assessed as 4-methylumbelliferrone by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of recombinant GBA1 preincuabated with compound for 30 mins using 4-methylumbelliferyl-B-glucoside substrate by fluorimetric assayMore data for this Ligand-Target Pair
