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Found 7 Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50224207'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataKi:  7nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataKi:  17nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataKi:  140nMAssay Description:Inhibition of human 11betaHSD1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50: >10nMAssay Description:Inhibition of human 11betaHSD1 in presence of 3% HSA by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50224207(2-(2-fluorophenylamino)-5-isopropylthiazol-4(5H)-o...)
Affinity DataIC50:  97nMAssay Description:Inhibition of human 11betaHSD1 in CHO cells assessed as conversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed