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Found 8 Enz. Inhib. hit(s) with Target = '2-Hydroxyacid oxidase 1' and Ligand = 'BDBM50463047'
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  4.50E+3nMAssay Description:Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  2.03E+4nMAssay Description:Inhibition of mouse N-terminal His-tagged glycolate oxidase expressed in BL21(DE3) Escherichia coli using glycolate as substrate by Cornish-Bowden pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human recombinant HAO1 assessed as detecting hydrogen peroxide using glycolic acid as substrate preincubated for 30 min followed by sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of mouse N-terminal His-tagged glycolate oxidase expressed in BL21(DE3) Escherichia coli using glycolate as substrate by Cornish-Bowden pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataIC50:  4.35E+4nMAssay Description:Inhibition of mouse recombinant glycolate oxidase expressed in Escherichia coli using glycolate as substrate by sulfonated DCIP dye-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.40E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 72 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  2.53E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 24 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Mus musculus)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataEC50:  3.30E+4nMAssay Description:Inhibition of glycolate oxidase in mouse Agxt1-/- hepatocytes using glycolate as substrate assessed as reduction in oxalate production after 48 hrs b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed