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Found 4 Enz. Inhib. hit(s) with Target = '3-hydroxy-3-methylglutaryl-coenzyme A reductase' and Ligand = 'BDBM50011032'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50011032(5-(4-Fluoro-phenyl)-1-[2-(4-hydroxy-6-oxo-tetrahyd...)
Affinity DataIC50:  3nMpH: 7.2Assay Description:All assays were carried out in a reaction buffer containing 100 nM KxPO4 at pH 7.2, 1 mM EDTA, 500 mM KCl and 1 mg/ml BSA. The concentrations of NADP...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50011032(5-(4-Fluoro-phenyl)-1-[2-(4-hydroxy-6-oxo-tetrahyd...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HMG-CoA reductase activity in partially purified rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50011032(5-(4-Fluoro-phenyl)-1-[2-(4-hydroxy-6-oxo-tetrahyd...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HMG-CoA reductase activity in partially purified rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Redx Pharma

US Patent
LigandPNGBDBM50011032(5-(4-Fluoro-phenyl)-1-[2-(4-hydroxy-6-oxo-tetrahyd...)
Affinity DataIC50:  25nMAssay Description:Inhibition of HMG-CoA reductase activity in partially purified rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed