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Found 3 Enz. Inhib. hit(s) with Target = '3-hydroxy-3-methylglutaryl-coenzyme A reductase' and Ligand = 'BDBM50432564'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  36.5nMpH: 7.4Assay Description:The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lys...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  37nMAssay Description:Inhibition of recombinant HMG-CoA reductase (unknown origin) after 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
National Taiwan University

US Patent
LigandPNGBDBM50432564(CHEMBL2347010 | US9115116, 8a)
Affinity DataIC50:  2.23E+4nMAssay Description:Inhibition of HMG-CoA reductase in human A549 cells after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed