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Found 3 Enz. Inhib. hit(s) with Target = 'Activated CDC42 kinase 1' and Ligand = 'BDBM17715'
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM17715(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Affinity DataKi:  70nMAssay Description:Inhibition of N-terminal His6-tagged ACK1 expressed in baculovirus infected Hi5 cells assessed as inhibition of autophosphorylation after 2 hrs by EL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM17715(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Affinity DataIC50:  110nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM17715(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 6 | N-[(2S)...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of ACK1 in mouse C8 cells assessed as decrease in cell viability after 20 to 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed