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Found 3 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member B1' and Ligand = 'BDBM50010283'
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010283(2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010283(2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
National Eye Institute

Curated by ChEMBL
LigandPNGBDBM50010283(2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...)
Affinity DataIC50:  54.7nMAssay Description:Inhibitory Activity against Human recombinant Aldose Reductase (wild type)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed