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Found 4 Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM116257'
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta(1 to 40 residues) levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  4nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta40 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed