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Found 3 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM50514219'
LigandPNGBDBM50514219(CHEMBL4438074 | US11274105, Example 181)
Affinity DataKi:  0.103nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50514219(CHEMBL4438074 | US11274105, Example 181)
Affinity DataIC50:  0.380nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50514219(CHEMBL4438074 | US11274105, Example 181)
Affinity DataIC50:  3.03nMAssay Description:For Mcl-1 TR-FRET assay with 5% human serum, the same assay condition was used except for the addition of 5% human serum (Bioreclamation, Westbury, N...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent