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Found 3 Enz. Inhib. hit(s) with Target = 'Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]' and Ligand = 'BDBM557740'
LigandPNGBDBM557740((1S,3'R,6'R,7'S,11'S,12'R)-7'-((2r,3aR,6aS)-5- ace...)
Affinity DataIC50:  0.217nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM557740((1S,3'R,6'R,7'S,11'S,12'R)-7'-((2r,3aR,6aS)-5- ace...)
Affinity DataIC50:  0.375nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM557740((1S,3'R,6'R,7'S,11'S,12'R)-7'-((2r,3aR,6aS)-5- ace...)
Affinity DataIC50:  0.537nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent