Found 27 Enz. Inhib. hit(s) with Target = 'Beta-2 adrenergic receptor' and Ligand = 'BDBM25769' TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
3D Structure (crystal)TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKi: 510nM ΔG°: -35.6kJ/mole IC50: 980nM EC50: 19nMpH: 7.4 T: 2°CAssay Description:In the binding assays, the results were expressed as percent inhibition of the control radioligand specific binding. The IC50 values (concentration c...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKi: 1.83E+3nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataIC50: 17nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of [3H]dihydroalprenolol from beta2-adrenoceptor after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring at basal tone assessed as bronchorelaxation activityMore data for this Ligand-Target Pair
Affinity DataKd: 520nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
Affinity DataKd: 1.16E+3nMAssay Description:Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against carbachol-induced co...More data for this Ligand-Target Pair
Affinity DataKd: 263nMAssay Description:Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA)More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 220nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 220nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 1.40E+3nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintilla...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 1.40E+3nMAssay Description:Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintilla...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataEC50: 251nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHO cells assessed as increase in intracellular cAMP level incubated for 1 hr by alphascree...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 1nMAssay Description:Displacement of [3H]-CGP12,177 from immobilized Halo tag-fused beta2 adrenoceptor (unknown origin) expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
Affinity DataKd: 245nMAssay Description:Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced co...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataEC50: 25nMAssay Description:Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataEC50: 200nMAssay Description:Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrMore data for this Ligand-Target Pair
Affinity DataEC50: 0.454nMAssay Description:Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced co...More data for this Ligand-Target Pair
Affinity DataEC50: 268nMAssay Description:Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against carbachol-induced co...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataEC50: 68nMAssay Description:Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assayMore data for this Ligand-Target Pair
Affinity DataKd: 570nMAssay Description:Apparent binding affinity constant to beta-2 adrenergic receptor determined using [3H]DHAMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataEC50: 0.110nMAssay Description:Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate r...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Institute Of Cell Signaling
Curated by PDSP Ki Database
Institute Of Cell Signaling
Curated by PDSP Ki Database
Affinity DataKd: 759nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
