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Found 5 Enz. Inhib. hit(s) with Target = 'Beta-glucuronidase' and Ligand = 'BDBM163637'
TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University of North Carolina At Chapel Hill

LigandPNGBDBM163637(3[(6,7Dimethyl2oxo1,2dihydroquinolin3yl)methyl]3(2...)
Affinity DataKi:  210nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163637(3[(6,7Dimethyl2oxo1,2dihydroquinolin3yl)methyl]3(2...)
Affinity DataIC50:  369nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163637(3[(6,7Dimethyl2oxo1,2dihydroquinolin3yl)methyl]3(2...)
Affinity DataIC50:  378nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163637(3[(6,7Dimethyl2oxo1,2dihydroquinolin3yl)methyl]3(2...)
Affinity DataEC50:  33.2nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163637(3[(6,7Dimethyl2oxo1,2dihydroquinolin3yl)methyl]3(2...)
Affinity DataEC50:  28.3nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent