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Found 6 Enz. Inhib. hit(s) with Target = 'Beta-glucuronidase' and Ligand = 'BDBM163641'
TargetBeta-glucuronidase(Escherichia coli (Enterobacteria))
University of North Carolina At Chapel Hill

LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataKi:  670nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  1.20E+3nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  1.27E+3nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataIC50:  8.89E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataEC50:  913nMAssay Description:PheG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-glucuronidase(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM163641(1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazo...)
Affinity DataEC50:  811nMAssay Description:PNPG Assay: Two ß-glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorb...More data for this Ligand-Target Pair
In DepthDetails US Patent