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Found 4 Enz. Inhib. hit(s) with Target = 'Bifunctional epoxide hydrolase 2' and Ligand = 'BDBM409002'
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409002(US10377744, Compound No. 23 | US11123311, Compound...)
Affinity DataKi:  0.870nMAssay Description:FRET assays to determine Ki for the compounds of Table I were carried out as described previously (Lee et al. Analytical Biochemistry 434 (2013) 259-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409002(US10377744, Compound No. 23 | US11123311, Compound...)
Affinity DataKi:  0.870nMAssay Description:Inhibition of recombinant human sEH expressed in baculovirus expression system assessed as reduction in ACPU binding incubated for 1 hr by FRET displ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409002(US10377744, Compound No. 23 | US11123311, Compound...)
Affinity DataKi:  0.870nMAssay Description:Binding affinity to purified recombinant human sEH by FRET-displacement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Eicosis

US Patent
LigandPNGBDBM409002(US10377744, Compound No. 23 | US11123311, Compound...)
Affinity DataKi:  0.870nMAssay Description:Any of a number of standard assays for determining epoxide hydrolase activity can be used to determine inhibition of sEH. For example, suitable assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent