Found 2 Enz. Inhib. hit(s) with Target = 'Broad substrate specificity ATP-binding cassette transporter ABCG2' and Ligand = 'BDBM50603614' TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute (Ba, Mm, Sl, Sva)
Curated by ChEMBL
National Cancer Institute (Ba, Mm, Sl, Sva)
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of human ABCG2 in human R5 cells assessed as inhibition of mitoxantrone efflux measured by flow cytometric analysisMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
National Cancer Institute (Ba, Mm, Sl, Sva)
Curated by ChEMBL
National Cancer Institute (Ba, Mm, Sl, Sva)
Curated by ChEMBL
Affinity DataEC50: 24nMAssay Description:Activation of human ABCG2-mediated ATPase activity preincubated for 2 mins followed by ATP addition and measured after 20 mins by colorimetric assayMore data for this Ligand-Target Pair
