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Found 3 Enz. Inhib. hit(s) with Target = 'C-X-C chemokine receptor type 3' and Ligand = 'BDBM610443'
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610443(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  1nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610443(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610443(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  46.3nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent