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Found 4 Enz. Inhib. hit(s) with Target = 'C-X-C chemokine receptor type 4' and Ligand = 'BDBM50155311'
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataIC50:  92nMAssay Description:Antagonist activity against CXCR4 in in human MOLT4 cells assessed as inhibition of SDF1alpha -induced Ca2+ mobilization after 30 mins by FACS analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at CXCR4 in human MOLT-4 cells assessed as decrease in SDF-1alpha induced cytosolic Ca2+ levels preincubated for 30 mins followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataIC50:  9.20E+4nMAssay Description:Inhibition of human recombinant CXCR4 expressed in THP-1 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
Shandong University

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataEC50:  1.90E+3nMAssay Description:Antagonist activity at CXCR4 expressed in human U373-MAGI cells assessed as inhibition of HIV1 gp120-induced cell-cell fusion between HIV1 NL4-3 enve...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed