Found 20 Enz. Inhib. hit(s) with Target = 'Carboxylic ester hydrolase' and Ligand = 'BDBM10404' 
Affinity DataKi: 8.00E+3nMAssay Description:Inhibitory activity against BuChE from horse serumMore data for this Ligand-Target Pair
Affinity DataKi: 3.20E+4nM ΔG°: -26.1kJ/moleT: 2°CAssay Description:AChE and BChE inhibitory activities were measured in vitro by a modified spectrophotometric method. all the inhibition studies were performed using ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.77E+3nMAssay Description:The IC50 values were determined using the spectrophotometric Ellman's method. All of the tested compounds were dissolved in 0.01 M DMSO and then ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of BChE from rat serum by Ellmans methodMore data for this Ligand-Target Pair
Affinity DataIC50: 7.96E+3nMAssay Description:The reaction mixture containing phosphate buffer, AChE or BChE and chosen compounds was prepared and intensively stirred. In given times (5, 10, 15, ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of horse serum BChEMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of equine serum BuChE by Ellman's assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibitory activity against BuChE from horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of equine serum BuChEMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMpH: 8.0 T: 2°CAssay Description:AChE and BChE inhibitory assay was carried out by following Ellman's methodology [Ellman et al., Biochem. Pharmacol., 7:88-95] using AChE (Electric e...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMpH: 8.0Assay Description:Galantamine was used as reference drugs. The synthesized quinazolines were dissolved in 0.1 M phosphate buffer of pH 8.0. (KH2PO4/K2HPO4. The reactio...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMpH: 8.0Assay Description:The synthesized compounds (each separately) were dissolved in a mixture of DMSO (1 ml) and methanol (9 ml) and then diluted in KH2PO4/K2HPO4 buffer (...More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of BuChE in horse serumMore data for this Ligand-Target Pair
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of equine serum ButyrylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+4nMpH: 8.0Assay Description:The substrates of the reaction were acetylthiocholine iodide and butyrylthiocholine iodide. 5,5'-dithio-bis(2-nitrobenzoic) acid (DTNB) was used ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.33E+4nMpH: 8.0 T: 2°CAssay Description:The assay was carried out according to the Ellman method [Ellman et al., Biochem. Pharmacol., 7:88-95], optimized for 96-well microplates using a Tec...More data for this Ligand-Target Pair
Affinity DataIC50: 6.19E+4nMAssay Description:The in vitro BuChE assay was performed similarly to the method described above. A standard enzyme activity curve was drawn for each enzyme using seve...More data for this Ligand-Target Pair
