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Found 8 Enz. Inhib. hit(s) with Target = 'Carboxylic ester hydrolase' and Ligand = 'BDBM8963'
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataKi:  2nMAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Universita Di Siena

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  10nMAssay Description:Inhibition of equine BChE incubated with compounf for 5 mins before addition of substrate S-butyrylthiocholine iodide by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  149nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  149nMAssay Description:Inhibition of rat serum BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  149nMAssay Description:Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  149nMAssay Description:Inhibition of rat BuChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hong Kong University of Science and Technology

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataIC50:  390nMAssay Description:Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed