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Found 3 Enz. Inhib. hit(s) with Target = 'Choline kinase alpha' and Ligand = 'BDBM50145946'
TargetCholine kinase alpha(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145946(CHEMBL3763931)
Affinity DataIC50:  85nMAssay Description:Inhibition of human N-terminal truncated ChoKalpha1 (75 to 457 residues) using choline chloride as substrate measured over 10 to 30 mins by coupled A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine kinase alpha(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145946(CHEMBL3763931)
Affinity DataIC50:  750nMAssay Description:Inhibition of ChoKalpha in human MDA-MB-415 cells assessed as reduction in phosphocholine level after 24 hrs by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholine kinase alpha(Homo sapiens (Human))
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50145946(CHEMBL3763931)
Affinity DataKd:  99nMAssay Description:Binding affinity to human N-terminal truncated ChoKalpha1 (75 to 457 residues) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed