Compile Data Set for Download or QSAR
maximum 50k data
Found 7 Enz. Inhib. hit(s) with Target = 'Complement factor D' and Ligand = 'BDBM354268'
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on PNH erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50:  4nMAssay Description:Inhibition of factor D in human serum assessed as decrease in alternative pathway of complement-mediated hemolysis of PNH erythrocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human factor D using C3b as substrate assessed as decrease in formation of factor B cleavage product BaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Human factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration is incubated with test compound at various conce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetComplement factor D(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM354268((2S,4R)-1-(2-(3-acetyl- 5-(2-methylpyrimidin- 5-yl...)
Affinity DataKd: <1nMAssay Description:Binding affinity to human factor D by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed