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Found 3 Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase' and Ligand = 'BDBM50250109'
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataIC50:  1.06E+4nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50250109(CHEMBL4062994)
Affinity DataKd:  6.70E+3nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed