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Found 4 Enz. Inhib. hit(s) with Target = 'Cyclic GMP-AMP synthase' and Ligand = 'BDBM50582657'
TargetCyclic GMP-AMP synthase(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582657(CHEMBL5082056)
Affinity DataIC50:  14nMAssay Description:Inhibition of human cGASMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Mus musculus)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582657(CHEMBL5082056)
Affinity DataIC50:  440nMAssay Description:Inhibition of mouse cGASMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Homo sapiens)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582657(CHEMBL5082056)
Affinity DataIC50:  2.69E+3nMAssay Description:Inhibition of human cGAS expressed in THP1-Dual cells transfected with HT-DNA assessed as suppression of lipofectamine 2000:ds-DNA complex induced ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclic GMP-AMP synthase(Mus musculus)
Shanghai Institute Of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582657(CHEMBL5082056)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of mouse cGAS expressed in RAW-Lucia ISG transfected with HT-DNA assessed as suppression of lipofectamine 2000:ds-DNA complex induced acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed