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Found 3 Enz. Inhib. hit(s) with Target = 'Cyclin-dependent kinase 9' and Ligand = 'BDBM167602'
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM167602(US9073922, 87 | US9796708, Example 87)
Affinity DataIC50:  10nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM167602(US9073922, 87 | US9796708, Example 87)
Affinity DataIC50:  14nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM167602(US9073922, 87 | US9796708, Example 87)
Affinity DataIC50:  18nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed