Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with Target = 'Cystic fibrosis transmembrane conductance regulator' and Ligand = 'BDBM301463'
TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301463BDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  1.53nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301463BDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  4.76nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301463BDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  31nMAssay Description:Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent

TargetCystic fibrosis transmembrane conductance regulator(Human)
Cystic Fibrosis Foundation Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 301463BDBM301463(US10131670, Example 87 | BDBM301464 | {1-[1-(2-Flu...)
Affinity DataEC50:  78.8nMAssay Description:Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
US Patent