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Found 3 Enz. Inhib. hit(s) with Target = 'Cystine/glutamate transporter' and Ligand = 'BDBM50376126'
TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  140nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human Calu1 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of Xct in human CCF-STTG1 cells assessed as glutamate release after 2 hrs by fluorometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystine/glutamate transporter(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50376126(ERASTIN)
Affinity DataIC50:  200nMAssay Description:Inhibition of cystine/glutamate antiporter system xc- in human HT1080 cells assessed as reduction in L-[3,3'-14C]-cystine uptake in presence of Na+ f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed