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Found 6 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 11B1, mitochondrial' and Ligand = 'BDBM50335360'
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50:  107nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50:  107nMAssay Description:Inhibition of human CYP11B1 expressed in hamster fibroblast using 100 nM [3H]-11-deoxycorticosterone as substrate after 25 mins by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50:  152nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50:  152nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using 11-deoxycorticosterone substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50:  152nMT: 2°CAssay Description:V79MZ cells expressing human CYP11B1 and human CYP11B2 genes, respectively, were grown on 24-well cell culture plates (8×10^5 cells per well) w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 11B1, mitochondrial(Rattus norvegicus)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335360(5-((1H-imidazol-1-yl)methyl)-2-phenylpyridine | CH...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of rat CYP11B1 expressed in hamster fibroblast using 500 nM [3H]-11-deoxycorticosterone as substrate after 7 hrs by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed