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Found 3 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 1B1' and Ligand = 'BDBM50269353'
TargetCytochrome P450 1B1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50269353(CHEMBL4105559)
Affinity DataIC50:  900nMAssay Description:Inhibition of human CYP1B1 bound to yeast microsomal membrane using 7-ethoxyresorufin as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50269353(CHEMBL4105559)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human CYP1B1 expressed in HEK293 cells using fluorogenic 7-ethoxyresorufin as substrate preincubated for 30 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
De Montfort University

Curated by ChEMBL
LigandPNGBDBM50269353(CHEMBL4105559)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of human CYP1B1 transfected in HEK293 cells assessed as cisplatin EC50 at 6 times IC50 by MTT assay (Rvb = 65 uM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed