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Found 5 Enz. Inhib. hit(s) with Target = 'Cytochrome P450 3A4' and Ligand = 'BDBM50268484'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-resorufin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) expressed in insect microsomes after 20 mins in presence of BFC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of recombinant CYP3A4 (unknown origin) expressed in insect microsomes after 45 mins in presence of BZR substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-...)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using 7-benzyloxy-4-trifluoromethylcoumarin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50268484((R)-4-(8-Fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of recombinant CYP3A4 expressed in insect microsomes after 20 mins in presence of BFC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed