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Compile Data Set for Download or QSAR
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Found
1
Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 4 subunit A/B' and Ligand = 'BDBM282'
Target
DNA topoisomerase 4 subunit A/B
(Escherichia coli (strain K12))
Vertex Pharmaceuticals
Ligand
BDBM282
((3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydrox...)
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Affinity Data
Ki: 110nM
Assay Description:
Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...
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