BindingDB PrimarySearch

Found 9 Enz. Inhib. hit(s) with Target = 'Death-associated protein kinase 1' and Ligand = 'BDBM2579'

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 0.5nMAssay Description:Inhibition of DAPK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 8.90nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 9.40nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 13nMAssay Description:Inhibition of DAPK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 13.1nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 13.1nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

IC50: 15.7nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 1.40nMAssay Description:Binding constant for DAPK1 kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Death-associated protein kinase 1(Homo sapiens (Human))
National Cancer Institute-Bethesda

Curated by ChEMBL

BDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)

Kd: 1.40nMAssay Description:Binding constant for DAPK1 kinase domainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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3D Structure (crystal)

Filter my 9 hits

Targets 1▿
- Death-associated protein kinase 1 9
Publications 8▿
- Eur J Med Chem 163: 453-480 (2019) 2
- Bioorg Med Chem Lett 27: 2029-2037 (2017) 1
- J Med Chem 52: 3191-204 (2009) 1
- Nat Biotechnol 26: 127-32 (2008) 1
- Eur J Med Chem 161: 456-467 (2019) 1
- Nat Biotechnol 29: 1046-51 (2011) 1
- Bioorg Med Chem 26: 1740-1750 (2018) 1
- Eur J Med Chem 141: 657-675 (2017) 1
Institutions 7▿
- Ambit Biosciences 2
- Gachon University 2
- University Of Florida 1
- Beijing Normal University 1
- National Cancer Institute-Bethesda 1
- Korea Institute Of Science And Technology (Kist) 1
- West Virginia University 1
Affinity: 0.5 to 16 nM▿
- IC50 7
- Kd 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1