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Found 6 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50051923'
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  72nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  72nMAssay Description:Inhibitory activity against rat liver dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  76nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  76nMAssay Description:Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 microM dihydrofolic acid)More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory activity against Dihydrofolate reductase from recombinant human (hDHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50051923(2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLA...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibitory activity against recombinant human dihydrofolate reductase(in 50 microM dihydrofolic acid)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed