Compile Data Set for Download or QSAR
maximum 50k data
Found 5 Enz. Inhib. hit(s) with Target = 'Dihydrofolate reductase' and Ligand = 'BDBM50329612'
TargetDihydrofolate reductase(Bacillus anthracis)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50329612(6-ethyl-5-(3-(5-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataKi:  330nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes)
University of Connecticut

US Patent
LigandPNGBDBM50329612(6-ethyl-5-(3-(5-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  52nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
University of Connecticut

US Patent
LigandPNGBDBM50329612(6-ethyl-5-(3-(5-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  59nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Connecticut

US Patent
LigandPNGBDBM50329612(6-ethyl-5-(3-(5-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  140nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aur...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Bacillus anthracis)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50329612(6-ethyl-5-(3-(5-methoxybiphenyl-3-yl)prop-1-ynyl)p...)
Affinity DataIC50:  973nMAssay Description:Inhibition of wild type Bacillus anthracis recombinant DHFRMore data for this Ligand-Target Pair