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Found 8 Enz. Inhib. hit(s) with Target = 'Dual specificity protein kinase TTK' and Ligand = 'BDBM50512456'
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged and sumo-tagged human TTK (1 to 275 residues) expressed in Escherichia coli pre-incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged and sumo-tagged human TTK (1 to 275 residues) expressed in Escherichia coli pre-incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged and sumo-tagged human TTK (1 to 275 residues) expressed in Escherichia coli pre-incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of full length recombinant N-terminal GST-tagged and sumo-tagged human TTK (1 to 275 residues) expressed in Escherichia coli pre-incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50512456(CHEMBL4469414)
Affinity DataIC50:  116nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed