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Found 4 Enz. Inhib. hit(s) with Target = 'Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]' and Ligand = 'BDBM536223'
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  202nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataKd:  43.8nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536223((2R)-1-((2S,4R)-4-hydroxy-2-(5-methyl-5-(4-(4-meth...)
Affinity DataKd:  29.3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent