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Found 3 Enz. Inhib. hit(s) with Target = 'Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]' and Ligand = 'BDBM536252'
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  62.8nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataIC50:  4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536252((2S)-1-((2S,4R)-2-(5-(4-Bromophenyl)-5-methyl-4,5-...)
Affinity DataKd:  9.08E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent