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Found 6 Enz. Inhib. hit(s) with Target = 'Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]' and Ligand = 'BDBM536268'
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataIC50:  4.35E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataIC50:  3.54E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataKd:  5.30E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataKd:  5.10E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM536268((5S)-2-((4R)-4-hydroxy-1-(2-(3-hydroxyisoxazol-5- ...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent