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Found 8 Enz. Inhib. hit(s) with Target = 'Elongin-B/Elongin-C [17-112]/von Hippel-Lindau disease tumor suppressor [55-213]' and Ligand = 'BDBM536284'
LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  418nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  1.50E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  1.57E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataIC50:  4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataKd:  2.12E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataKd:  1.02E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
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LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataKd:  6.15E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
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In DepthDetails US Patent
LigandPNGBDBM536284((5S)-2-((4R)-4-hydroxy-1-(3-methyl-2-(1-methyl-1H-...)
Affinity DataKd:  128nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent