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Found 4 Enz. Inhib. hit(s) with Target = 'Endothelial lipase' and Ligand = 'BDBM319014'
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Affinity DataIC50:  29nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Affinity DataIC50:  600nMAssay Description:Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human endothelial lipase using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed