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Found 5 Enz. Inhib. hit(s) with Target = 'Endothelin-1 receptor' and Ligand = 'BDBM50105051'
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.00620nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0150nMAssay Description:Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at ET-A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed