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Found 6 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50160870'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  9nMAssay Description:Inhibition of EGFR L858R mutant in human H3255 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR Del ex19 mutant in human HCC827 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  25nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cells assessed as suppression of cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  31nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  95nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50160870(CHEMBL3787344 | WO2022090481, Example nazartinib)
Affinity DataIC50:  161nMAssay Description:Inhibition of wild type EGFR phosphorylation in human HaCaT cells incubated for 3 hrs by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed